UOP NRP507 Week 2 Discussion Latest 2021 July
NRP507 Advanced Pharmacology
Week 2 Discussion
Ominous Octet
The “Ominous Octet” phrase coined by Dr. Ralph DeFronzo refers to eight main core defects contributing to hyperglycemia, occurring with diabetes.
In a minimum of 175-300 words, provide seven main core defects contributing to hyperglycemia. One main core is already provided in the example below.
Include the following in your response:
Organ: The organ that is contributing to the hyperglycemia
Defect: A phrase to describe the defect
Drug Class: At least one drug class (not drug name)that works on the defect
Mechanism of Action: Explain the mechanism of action
Why is it important for an FNP to understand each defect?
Example
Organ: Pancreas
Defect: Decreased beta cell production
Drug Class: Sulfonylurea
Mechanism of Action: Stimulates release of insulin from beta cells
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