MPH501 Module 7 Exercise Latest 2020 January
MPH501 Quantitative Methods for Public Health Application
Module 7 Exercise
Question 1 A clinical trial is run to evaluate the efficacy of a new medication to relieve pain in patients undergoing total knee replacement surgery. In the trial, patients are randomly assigned to receive either the new medication or the standard medication. After receiving the assigned medication, patients are asked to report their pain on a scale of 0-100 with higher scores indicative of more pain. Data on the primary outcome are shown below.
|
Sample Size |
Mean Pain Score |
Standard Deviation of Pain Score |
|
|
New Medication |
60 |
30.31 |
7.52 |
|
Standard Medication |
60 |
53.85 |
7.44 |
Because procedures can be more complicated in older patients, the investigators are concerned about confounding by age. For analysis, patients are classified into two age groups, less than 65 and 65 years of age and older. The data are shown below.
|
Age < 65 Years |
Sample Size |
Mean Pain Score |
Standard Deviation of Pain Score |
|
New Medication |
40 |
25.30 |
2.46 |
|
Standard Medication |
25 |
45.51 |
1.83 |
|
Total: Age < 65 Years |
65 |
33.07 |
10.16 |
|
|
|
|
|
|
Age 65+ Years |
Sample Size |
Mean Pain Score |
Standard Deviation of Pain Score |
|
New Medication |
20 |
40.33 |
2.16 |
|
Standard Medication |
35 |
59.80 |
2.49 |
|
Total: Age 65+ |
55 |
52.72 |
9.74 |
Is there a statistically significant difference in mean pain scores between patients assigned to the new medication as compared to the standard medication? Run the appropriate test at ?=0.05. (Ignore age in this analysis.)
Question 2 Use the data in Problem 7 to determine whether age a confounding variable. Run the tests of hypothesis to determine whether the age is related to treatment assignment and whether there is a difference in mean pain scores by age group. Is age a confounder? Justify your conclusion.
|
Age Group and Treatment |
New |
Standard Medication |
|
Age < 65 |
40 |
25 |
|
Age 65+ |
20 |
35 |
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