Acute Kidney Transplant Rejection Case Study Analysis

GMU Acute Kidney Transplant Rejection Case Study Analysis Paper

CASE STUDY ANALYSIS

In this Assignment, you examine a case study and analyze the symptoms presented. You identify cell, gene, and/or process elements that may be factored in the diagnosis, and you explain the implications to patient health.

Case study Scenerio

A 34-year-old Hispanic-American male with end-stage renal disease received kidney transplant from a cadaver donor, as no one in his family was a good match. His post-operative course was uneventful, and he was discharged with the antirejection drugs Tacrolimus (Prograf), Cyclosporine (Neoral), and Imuran (Azathioprine). He did well for 3 months and had returned to his job as a policeman. Six months after his transplant, he began to gain weight, had decreased urine output, was very fatigued, and began to run temperatures up to 101?F. He was evaluated by his nephrologist, who diagnosed acute kidney transplant rejection.

RESOURCES

McCance, K. L. & Huether, S. E. (2019). Pathophysiology: The biologic basis for disease in adults and children (8th ed.). St. Louis, MO: Mosby/Elsevier.

Chapter 7: Innate Immunity: Inflammation and Wound Healing

Chapter 8: Adaptive Immunity (stop at Generation of clonal diversity); Summary Review

Chapter 9: Alterations in Immunity and Inflammation (stop at Deficiencies in immunity); Summary Review

Chapter 10: Infection (stop at Infectious parasites and protozoans); (start at HIV); Summary Review

Chapter 11: Stress and Disease (stop at Stress, illness & coping); Summary Review

Chapter 12: Cancer Biology (stop at Resistance to destruction); Summary Review

Chapter 13: Cancer Epidemiology (stop at Environmental-Lifestyle factors); Summary Review

Justiz-Vaillant, A. A., & Zito, P. M. (2019). Immediate hypersensitivity reactionsLinks to an external site.. In StatPearls. Treasure Island, FL: StatPearls Publishing. Retrieved from https://www.ncbi.nlm.nih.gov/books/NBK513315/

Credit Line: Immediate Hypersensitivity Reactions – StatPearls – NCBI Bookshelf. (2019, June 18). Retrieved from https://www.ncbi.nlm.nih.gov/books/NBK513315/. Used with permission of Stat Pearls.

 

To prepare:

Examine the case study above.

The Assignment

Develop a case study analysis in which you:

Explain why you think the patient presented the symptoms described.

Identify the genes that may be associated with the development of the disease.

Explain the process of immunosuppression and the effect it has on body systems.